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Marked for life? Effects of early cage-cleaning frequency, delivery batch, and identification tail-marking on rat anxiety profiles.

Abstract:

Daily handling of preweanling rats reduces their adult anxiety. Even routine cage-cleaning, involving handling, reduces adult anxiety compared with controls. Cage-cleaning regimes differ between animal breeders, potentially affecting rodent anxiety and experimental results. Here, 92 adult male rats given different cage-cleaning rates as pups, were compared on plus-maze, hyponeophagia, corticosterone, and handling tests. They were pair-housed and half were tail-marked for identification. Anxie...

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Publisher copy:
10.1002/dev.20279

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Developmental psychobiology
Volume:
50
Issue:
3
Pages:
266-277
Publication date:
2008-04-05
DOI:
EISSN:
1098-2302
ISSN:
0012-1630
URN:
uuid:eea0847f-ff3a-446c-ab23-4174694c0095
Source identifiers:
4053
Local pid:
pubs:4053

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