A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.

Journal article

Mutations in LRRK2 (leucine-rich repeat kinase 2) represent a significant component of both sporadic and familial PD (Parkinson's disease). Pathogenic mutations cluster in the enzymatic domains of LRRK2, and kinase activity seems to correlate with cytotoxicity, suggesting the possibility of kinase-based therapeutic strategies for LRRK2-associated PD. Apart from cytotoxicity, changes in autophagy have consistently been observed upon overexpression of mutant, or knockdown of endogenous, LRRK2. ...

Expand abstract

Authors: Gómez-Suaga, P; Churchill, G; Patel, S; Hilfiker, S

• Publication status: Published
• Journal: Biochemical Society transactions
• Volume: 40
• Issue: 5
• Pages: 1140-1146
• Publication date: 2012-10-01
• DOI: 10.1042/bst20120138
• EISSN: 1470-8752
• ISSN: 0300-5127
• Language: English
• Keywords: Protein-Serine-Threonine Kinases; Parkinson Disease; NADP; Mutation; Humans; Lysosomes; Calcium Signaling; Autophagy