Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria.

Journal article

Neisseria meningitidis and Neisseria gonorrhoeae are globally important pathogens, which in part owe their success to their ability to successfully evade human immune responses over long periods. The phase-variable opacity-associated (Opa) adhesin proteins are a major surface component of these organisms, and are responsible for bacterial adherence and entry into host cells and interactions with the immune system. Most immune interactions are mediated via binding to members of the carcinoembr...

Expand abstract

Authors: Sadarangani, M; Pollard, A; Gray-Owen, S

• Publication status: Published
• Journal: FEMS microbiology reviews
• Volume: 35
• Issue: 3
• Pages: 498-514
• Publication date: 2011-05-01
• DOI: 10.1111/j.1574-6976.2010.00260.x
• EISSN: 1574-6976
• ISSN: 0168-6445
• Language: English
• Keywords: Humans; Neisseria meningitidis; Cell Adhesion Molecules; Animals; Carcinoembryonic Antigen; Protein Binding; Bacterial Outer Membrane Proteins; Meningitis, Meningococcal