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Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells.

Abstract:

A bias of T cell immunity towards type 2 (Th2) is thought to be critical for normal pregnancy. Pathological pregnancies, such as pre-eclampsia, are characterised by cell-mediated (Th1) immune dominance. The Th1/Th2 paradigm, however, is too simplistic. Normal pregnancy is associated with a systemic inflammatory response which increases throughout gestation. This inflammatory response is exaggerated in pre-eclampsia, a syndrome of the third trimester. T helper (Th) cells are considered the pri...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200425929

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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Role:
Author
Journal:
European journal of immunology
Volume:
35
Issue:
10
Pages:
3054-3063
Publication date:
2005-10-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:ee6473e4-aae6-4c4a-9888-3b92b4b0a334
Source identifiers:
248201
Local pid:
pubs:248201

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