Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells.

Journal article

A bias of T cell immunity towards type 2 (Th2) is thought to be critical for normal pregnancy. Pathological pregnancies, such as pre-eclampsia, are characterised by cell-mediated (Th1) immune dominance. The Th1/Th2 paradigm, however, is too simplistic. Normal pregnancy is associated with a systemic inflammatory response which increases throughout gestation. This inflammatory response is exaggerated in pre-eclampsia, a syndrome of the third trimester. T helper (Th) cells are considered the pri...

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Authors: Borzychowski, A; Croy, B; Chan, W; Redman, C; Sargent, I

• Publication status: Published
• Journal: European journal of immunology
• Volume: 35
• Issue: 10
• Pages: 3054-3063
• Publication date: 2005-10-01
• DOI: 10.1002/eji.200425929
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Adult; Receptors, Cell Surface; Killer Cells, Natural; Th1 Cells; Pre-Eclampsia; Humans; Female; Interleukin-18; Pregnancy; Membrane Proteins; Flow Cytometry; Th2 Cells