Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.

Journal article

CD28-delivered costimulatory signals are required to induce NF-kappaB activation in response to TCR stimulation. We have recently demonstrated that the mitogen-activated kinase kinase 1 (MEKK1), a kinase known to regulate the c-jun N-terminal kinase (JNK) pathway, is also involved in the CD28- and TCR-induced inhibitor of kappaB factor (IkappaB) kinases (IKK) and NF-kappaB activation. Searching for molecules that couple TCR and CD28 to MEKK1, we found that the guanine nucleotide exchange fact...

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Authors: Marinari, B; Costanzo, A; Viola, A; Michel, F; Mangino, G

• Publication status: Published
• Journal: European journal of immunology
• Volume: 32
• Issue: 2
• Pages: 447-456
• Publication date: 2002-02-01
• DOI: 10.1002/1521-4141(200202)32:2<447::aid-immu447>3.0.co;2-5
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Humans; Signal Transduction; MAP Kinase Kinase Kinase 1; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins; Genes, Reporter; Antigens, CD28; Proto-Oncogene Proteins c-vav; NF-kappa B; Jurkat Cells; T-Lymphocytes; Lymphocyte Activation; rac1 GTP-Binding Protein; I-kappa B Kinase; Receptors, Antigen, T-Cell; Cell Cycle Proteins; Mutation; Luciferases