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Palladium-catalyzed intramolecular O-arylation of enolates: application to benzo[b]furan synthesis.

Abstract:
[reaction: see text] A catalyst generated from Pd2(dba)3 and the ligand DPEphos effects intramolecular C-O bond formation between enolates and aryl halides in the conversion of 1-(2-haloaryl)ketones directly into the corresponding benzofurans. Both cyclic and acyclic ketones are efficient substrates. Thio ketones can also be employed allowing the preparation of the corresponding benzothiophenes.
Publication status:
Published

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Publisher copy:
10.1021/ol047993g

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Journal:
Organic letters More from this journal
Volume:
6
Issue:
25
Pages:
4755-4757
Publication date:
2004-12-01
DOI:
EISSN:
1523-7052
ISSN:
1523-7060


Language:
English
Pubs id:
pubs:52462
UUID:
uuid:ee59917a-7b34-41af-9b69-5315befab3ad
Local pid:
pubs:52462
Source identifiers:
52462
Deposit date:
2012-12-19
ARK identifier:

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