Journal article

The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, Kenya.

Abstract:: The mechanisms of drug resistance development in the Plasmodium falciparum parasite to lumefantrine (LUM), commonly used in combination with artemisinin are still unclear. We assessed the polymorphisms of Pfmspdbl2, for associations with LUM activity in a Kenyan population. MSPDBL2 codon 591S was associated with reduced susceptibility to LUM (p=0.04). The high frequency of Pfmspdbl2 codon 591S in Kenya, may be driven by the widespread use of lumefantrine in the artemisinin combination therapy, Coartem.

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APA Style

Ochola-Oyier, L., Okombo, J., Mwai, L., Kiara, S., Pole, L., Tetteh, K., Nzila, A., & Marsh, K. (2014). The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, Kenya. Antimicrob Agents Chemother.

MLA Style

Ochola-Oyier, L, et al. “The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine in Vitro Drug Responses in Plasmodium Falciparum Isolates from Kilifi, Kenya.” Antimicrob Agents Chemother, 2014.

Chicago Style

Ochola-Oyier, L, J Okombo, L Mwai, et al. 2014. “The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine in Vitro Drug Responses in Plasmodium Falciparum Isolates from Kilifi, Kenya.” Antimicrob Agents Chemother.
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Publisher copy:: 10.1128/AAC.03522-14

Authors

+ Ochola-Oyier, L More by this author

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+ Okombo, J More by this author

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+ Mwai, L More by this author

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+ Kiara, S More by this author

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+ Pole, L More by this author

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Journal:: Antimicrob Agents Chemother More from this journal
Publication date:: 2014-12-22
DOI:: 10.1128/AAC.03522-14
EISSN:: 1098-6596

Language:: English
Pubs id:: pubs:501559
UUID:: uuid:ee5473ad-22d2-4290-81e9-713ba680655d
Local pid:: pubs:501559
Source identifiers:: 501559
Deposit date:: 2015-01-07
ARK identifier:: ark:/29072/ora_ee5473ad22d2429081e9713ba680655d

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Copyright date:: 2014

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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