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The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.

Abstract:

CD1d-restricted lymphocytes recognize a broad lipid range. However, how CD1d-restricted lymphocytes translate T cell receptor (TCR) recognition of lipids with similar group heads into distinct biological responses remains unclear. Using a soluble invariant NKT (iNKT) TCR and a newly engineered antibody specific for alpha-galactosylceramide (alpha-GalCer)-human CD1d (hCD1d) complexes, we measured the affinity of binding of iNKT TCR to hCD1d molecules loaded with a panel of alpha-GalCer analogu...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20062342

Authors


McCarthy, C More by this author
Shepherd, D More by this author
Stronge, VS More by this author
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Journal:
The Journal of experimental medicine
Volume:
204
Issue:
5
Pages:
1131-1144
Publication date:
2007-05-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:ee4dd871-d9b8-4f9c-a025-8d905602c7a4
Source identifiers:
9822
Local pid:
pubs:9822

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