Journal article
TEDDI: Radiotherapy delivery in deep inspiration for pediatric patients - A NOPHO feasibility study
- Abstract:
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Background
Radiotherapy (RT) delivered in deep inspiration breath-hold (DIBH) is a simple technique, in which changes in patient anatomy can significantly reduce the irradiation of the organs at risk (OARs) surrounding the treatment target. DIBH is routinely used in the treatment of some adult patients to diminish the risk of late effects; however, no formalized studies have addressed the potential benefit of DIBH in children.
Methods/Design
TEDDI is a multicenter, non-randomized, feasibility study. The study investigates the dosimetric benefit of RT delivered in DIBH compared to free breathing (FB) in pediatric patients. Also, the study aims to establish the compliance to DIBH and to determine the accuracy and reproducibility in a pediatric setting. Pediatric patients (aged 5–17 years) with a tumor in the mediastinum or upper abdomen with the possible need of RT will be included in the study. Written informed consent is obligatory. Prior to any treatment, patients will undergo a DIBH training session followed by a diagnostic PET/CT- or CT-staging scan in both DIBH and FB. If the patient proceeds to RT, a RT planning CT scan will be performed in both DIBH and FB and two separate treatment plans will be calculated. The superior treatment plan, i.e. equal target coverage and lowest overall dose to the OARs, will be chosen for treatment. Patient comfort will be assessed daily by questionnaires and by adherence to the respiratory management procedure.
Discussion
RT in DIBH is expected to diminish irradiation of the OARs surrounding the treatment target and thereby reduce the risk of late effects in childhood cancer survivors.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 560.4KB, Terms of use)
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- Publisher copy:
- 10.1186/s13014-018-1003-4
Authors
- Publisher:
- BioMed Central
- Journal:
- Radiation Oncology More from this journal
- Volume:
- 13
- Issue:
- 1
- Pages:
- 56
- Publication date:
- 2018-03-27
- Acceptance date:
- 2018-03-16
- DOI:
- EISSN:
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1748-717X
- ISSN:
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1748-717X
- Pmid:
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29587881
- Language:
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English
- Keywords:
- Pubs id:
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pubs:833478
- UUID:
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uuid:ee4837ab-401c-4472-ba91-184d7425a7bd
- Local pid:
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pubs:833478
- Deposit date:
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2018-11-26
Terms of use
- Copyright holder:
- Lundgaard et al
- Copyright date:
- 2018
- Notes:
- © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Licence:
- CC Attribution (CC BY)
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