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Journal article

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.

Abstract:

CONTEXT: Thyroid-associated ophthalmopathy (TAO) is a sight-threatening autoimmune disease in which de novo adipogenesis has been identified as a fundamental pathogenic mechanism. 11beta-Hydroxysteroid dehydrogenase 1 (11beta-HSD1) increases cortisol bioavailability and is pivotal in mediating glucocorticoid responses in adipose tissue and inflammation. OBJECTIVE: In this study we characterize 11beta-HSD1 as a determinant of the adipogenic and inflammatory pathways in TAO orbital fat (OF) com...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2009-0873

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Durrani, OM More by this author
Bujalska, IJ More by this author
Gathercole, LL More by this author
Tomlins, PJ More by this author
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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
95
Issue:
1
Pages:
398-406
Publication date:
2010-01-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:ee3dbd26-972d-40c0-8cb5-02c75e058cd0
Source identifiers:
482082
Local pid:
pubs:482082

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