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Journal article

Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma.

Abstract:

Fatty acid desaturases such as steaoryl-CoA desaturase (SCD) convert saturated to unsaturated fatty acids and are involved in lipogenesis. Observational and animal data suggest that SCD-1 activity is related to insulin sensitivity. However, the effects of insulin-sensitizing drugs on SCD gene expression and desaturase activities are unknown in humans. In a randomized, placebo-controlled, double-blind, crossover study, 24 subjects with type 2 diabetes and one subject with partial lipodystrophy...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.54.5.1379

Authors


Risérus, U More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Neville, MJ More by this author
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Journal:
Diabetes
Volume:
54
Issue:
5
Pages:
1379-1384
Publication date:
2005-05-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:ee2dc9a1-40d8-4d3a-ba93-45364bbee21f
Source identifiers:
16934
Local pid:
pubs:16934

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