Effects of monoclonal antibodies to the alpha and beta chains of the human lymphocyte function-associated (H-LFA-1) antigen on T lymphocyte functions.

Journal article

The ability of two antibodies, one specific for the alpha chain, p180, and the other for the beta chain, p95, of the human lymphocyte function-associated (LFA-1) antigens, to inhibit T cell function was measured. Both antibodies inhibited T cell-mediated lysis of virus-infected target cells and of K562 cells. Only the anti-beta chain antibody inhibited natural killer cell lysis of K562. The antibodies inhibited cytotoxic T lymphocyte cell (CTL) lysis of HLA-mismatched target cells in the pres...

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Authors: Dongworth, D; Gotch, F; Hildreth, J; Morris, A; Mcmichael, A

• Publication status: Published
• Journal: European journal of immunology
• Volume: 15
• Issue: 9
• Pages: 888-892
• Publication date: 1985-09-01
• DOI: 10.1002/eji.1830150905
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Lymphocyte Activation; T-Lymphocytes, Cytotoxic; Antigens, Bacterial; Cytotoxicity, Immunologic; Lectins; Lymphocyte Function-Associated Antigen-1; Antibodies, Monoclonal; Killer Cells, Natural; T-Lymphocytes; Humans; Antigens, Surface; Interferon-gamma; Antigens, Viral; Binding, Competitive