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Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium.

Abstract:

The folate pathway represents a powerful target for combating rapidly dividing systems such as cancer cells, bacteria and malaria parasites. Whereas folate metabolism in mammalian cells and bacteria has been studied extensively, it is understood less well in malaria parasites. In two articles, we attempt to reconstitute the malaria folate pathway based on available information from mammalian and microbial systems, in addition to Plasmodium-genome-sequencing projects. In part I, we focused on ...

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Publication status:
Published

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Publisher copy:
10.1016/j.pt.2005.05.008

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
Journal:
Trends in parasitology
Volume:
21
Issue:
7
Pages:
334-339
Publication date:
2005-07-05
DOI:
EISSN:
1471-5007
ISSN:
1471-4922
URN:
uuid:ee27b4b8-ac2e-4b8a-9ed1-49446896bbee
Source identifiers:
39607
Local pid:
pubs:39607

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