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Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1.

Abstract:

The tumor antigen 5T4/WAIF1 (Wnt-activated inhibitory factor 1; also known as Trophoblast glycoprotein TPBG) is a cell surface protein targeted in multiple cancer immunotherapy clinical trials. Recently, it has been shown that 5T4/WAIF1 inhibits Wnt/β-catenin signaling, a signaling system central to many developmental and pathological processes. Wnt/β-catenin signaling is controlled by multiple inhibitors and activators. Here, we report crystal structures for the extracellular domain of 5T4/W...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2014.01.009

Authors


Malinauskas, T More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Journal:
Structure (London, England : 1993)
Volume:
22
Issue:
4
Pages:
612-620
Publication date:
2014-04-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:ee15971f-3239-4b93-bc33-bfd309be2a80
Source identifiers:
451082
Local pid:
pubs:451082

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