Toll-like receptors and malaria – sensing and susceptibility

Journal article

Abstract:: Toll-Like Receptors (TLRs) are important mediators of the innate immune response to pathogens, including malaria. Of the ten human and twelve mouse TLRs, TLR2, TLR4, TLR7 and TLR9 are known to detect malarial antigens and induce anti-malarial immune responses. Multiple immune cell populations express TLRs, and much has been done to elucidate the TLR-mediated immune response to malaria infections, in particular the involvement of TLRs in severe malaria pathogenesis. Here we review the role TLRs play in parasite detection, immune response, and severe malaria, with a focus on recent findings. Furthermore, the use of TLR ligands as malarial vaccine adjuvants is discussed, as this could have great potential in improving efficacy of vaccine candidates.

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Publisher:: Longdom Publishing
Journal:: Journal of Tropical Diseases and Public Health More from this journal
Volume:: 2
Issue:: 1
Pages:: 1-7
Publication date:: 2013-12-20
Acceptance date:: 2013-12-18
DOI:: 10.4172/2329-891X.1000126
EISSN:: 2329-891X

Keywords:: toll-like receptors

SBTMR

X-ray crystallography

interferon regulatory factors
Pubs id:: pubs:734387
UUID:: uuid:ee1531f0-02e0-4735-8a13-d7b7607960b4
Local pid:: pubs:734387
Source identifiers:: 734387
Deposit date:: 2017-10-06

Copyright holder:: Eriksson EM, et al
Notes:: Copyright: © 2013 Eriksson EM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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