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Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

Abstract:

Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are complex chronic inflammatory conditions of the gastrointestinal tract that are driven by perturbed cytokine pathways. Anti-tumour necrosis factor-α (TNF) antibodies are a mainstay therapeutic approach for IBD. However, up to 40% of patients are non-responsive to anti-TNF agents, and identifying alternative therapeutic targets is a priority. Here we show that expression of the cytokine Oncostatin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nm.4307

Authors


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Department:
Oxford, MSD, NDM, NDORMS, KIR
Hegazy, AN More by this author
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Department:
Oxford, Colleges and Halls, Somerville College
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Department:
Oxford, MSD, NDORMS, KIR
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Funding agency for:
West, NR
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Funding agency for:
Maloy, KJ
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Funding agency for:
Powrie, F
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Medicine Journal website
Volume:
23
Pages:
579–589
Publication date:
2017-04-05
Acceptance date:
2017-02-17
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Pubs id:
pubs:687875
URN:
uri:ee0770b7-453a-496e-859f-1dedb7afe2e2
UUID:
uuid:ee0770b7-453a-496e-859f-1dedb7afe2e2
Local pid:
pubs:687875
Language:
English
Keywords:

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