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Dynamic coinfection with multiple viral subtypes in acute hepatitis C

Abstract:

Introduction. Acute hepatitis C virus (HCV) infection is rarely studied, but virus sequence evolution and host-virus dynamics during this early stage may influence the outcome of infection. Hypervariable region 1 (HRV1) is genetically diverse and under selective pressure from the host immune response. We analyzed HRV1 evolution by frequent sampling of an acutely infected HCV cohort.

Methods. Three or more pretreatment samples were obtained from each of 10 acutely infected subjects. P...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1086/657317

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Institution:
University of Oxford
Department:
Medical Sciences Division - Pathogen Research,The Peter Medawar Building for
Role:
Author
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Institution:
Medical University of Vienna, Vienna, Austria
Department:
Institute of Virology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Pathogen Research,The Peter Medawar Building for
Role:
Author
More by this author
Institution:
Medical University of Vienna, Vienna, Austria
Department:
Department of Internal Medicine,Gastroenterology and Hepatology
Role:
Author
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Institution:
Imperial College, London
Department:
Department of Hepatology
Role:
Author
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Wellcome Trust More from this funder
Medical Research Council More from this funder
James Martin 21st Century School, Oxford More from this funder
US National Institutes of Health More from this funder
UK National Institute for Health Research Biomedical Research Centre Programme, Oxford More from this funder
Publisher:
Oxford University Press
Journal:
Journal of Infectious Diseases Journal website
Volume:
202
Issue:
12
Pages:
1770-1779
Publication date:
2010-01-01
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:edfeac9b-55a2-4998-a0c9-aa18fd9f35a4
Local pid:
ora:6016
Language:
English
Keywords:
Subjects:

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