Dynamic coinfection with multiple viral subtypes in acute hepatitis C
Introduction. Acute hepatitis C virus (HCV) infection is rarely studied, but virus sequence evolution and host-virus dynamics during this early stage may influence the outcome of infection. Hypervariable region 1 (HRV1) is genetically diverse and under selective pressure from the host immune response. We analyzed HRV1 evolution by frequent sampling of an acutely infected HCV cohort.
Methods. Three or more pretreatment samples were obtained from each of 10 acutely infected subjects. P...Expand abstract
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