Co-culture of bone marrow fibroblasts and endothelial cells on modified polycaprolactone substrates for enhanced potentials in bone tissue engineering.

Journal article

The creation of a vascularized bed makes the survival of seeded cells on 3-dimensional scaffolds much more likely. However, relying purely on random capillary ingrowth into the porous scaffolds from the host may compromise vascularization of a scaffold. One solution is to transplant cells capable of differentiating into new blood vessels into the scaffolds to accelerate the creation of a vascularized scaffold. Because endothelial cells are the key cells involved in blood vessel formation, the...

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Authors: Choong, C; Hutmacher, D; Triffitt, J

• Publication status: Published
• Journal: Tissue engineering
• Volume: 12
• Issue: 9
• Pages: 2521-2531
• Publication date: 2006-09-01
• DOI: 10.1089/ten.2006.12.2521
• EISSN: 1557-8690
• ISSN: 1076-3279
• Language: English
• Keywords: Cell Differentiation; Organ Specificity; Coated Materials, Biocompatible; Bone Marrow Cells; Humans; Cell Line; Cell Adhesion; Fibroblasts; Coculture Techniques; Tissue Engineering; Bone Substitutes; Skin; Endothelial Cells; Neovascularization, Physiologic; Polyesters