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Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin.

Abstract:

BACKGROUND: Impaired vitamin B(12) function and decreased vitamin B(12) status have been associated with neurological and cognitive impairment. Current assays analyze total vitamin B(12) concentration, only a small percentage of which is metabolically active. Concentrations of this active component, carried on holotranscobalamin (holoTC), may be of greater relevance than total vitamin B(12). METHODS: We compared the utility of serum holoTC with conventional vitamin B(12) for detection of vita...

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Publication status:
Published

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Journal:
Clinical chemistry
Volume:
53
Issue:
5
Pages:
963-970
Publication date:
2007-05-05
DOI:
EISSN:
1530-8561
ISSN:
0009-9147
URN:
uuid:edee9230-e3a8-432f-90c7-c6fa802c618a
Source identifiers:
49245
Local pid:
pubs:49245

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