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The linear assembly of a pure glycoenzyme.

Abstract:
A labor of love: The synthesis of an active pure enzyme (RNase) glycoform by the native chemical ligation of a (glyco)peptide and peptide thioester fragments required numerous painstaking steps: the strategy was optimized, active inteins accessed, redox conditions fine-tuned, and glycoamino acid building blocks synthesized.
Publication status:
Published

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Publisher copy:
10.1002/anie.200806246

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Angewandte Chemie (International ed. in English)
Volume:
48
Issue:
26
Pages:
4674-4678
Publication date:
2009
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:ede997db-40c2-4883-80dd-1e3cd31bec4a
Source identifiers:
34708
Local pid:
pubs:34708

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