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Placebo-controlled trial of cytisine for smoking cessation.

Abstract:

BACKGROUND: Cytisine, a partial agonist that binds with high affinity to the α(4)β(2) nicotinic acetylcholine receptor, is a low-cost treatment that may be effective in aiding smoking cessation. This study assessed the efficacy and safety of cytisine as compared with placebo. METHODS: We conducted a single-center, randomized, double-blind, placebo-controlled trial. Participants were randomly assigned to receive cytisine or matching placebo for 25 days; participants in both groups received a m...

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Publisher copy:
10.1056/nejmoa1102035

Authors


Zatonski, W More by this author
Cedzynska, M More by this author
Lewandowska, D More by this author
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Journal:
The New England journal of medicine
Volume:
365
Issue:
13
Pages:
1193-1200
Publication date:
2011-09-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
URN:
uuid:ede512db-36f5-47c2-b2ee-50cadab7f0e4
Source identifiers:
351517
Local pid:
pubs:351517

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