Journal article

Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein.

Abstract:: Variation in the immunodominant T cell epitopes Th2R and Th3R of the Plasmodium falciparum circumsporozoite protein has been analysed from Gambian clinical isolates using the polymerase chain reaction. The degree of polymorphism in these epitopes is more extensive than that found in several geographically diverse laboratory isolates. These findings strongly suggest that it will not be feasible to include all variants in a polyvalent subunit sporozoite vaccine.

Publication status:: Published

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APA Style

Lockyer, M., Marsh, K., & Newbold, C. (1989). Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein. Molecular and Biochemical Parasitology, 37(2), 275–280.

MLA Style

Lockyer, M, et al. “Wild Isolates of Plasmodium Falciparum Show Extensive Polymorphism in T Cell Epitopes of the Circumsporozoite Protein.” Molecular and Biochemical Parasitology, vol. 37, no. 2, 1989, pp. 275–80.

Chicago Style

Lockyer, M, K Marsh, and C Newbold. 1989. “Wild Isolates of Plasmodium Falciparum Show Extensive Polymorphism in T Cell Epitopes of the Circumsporozoite Protein.” Molecular and Biochemical Parasitology 37 (2): 275–80.
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Publisher copy:: 10.1016/0166-6851(89)90159-x

Authors

+ Lockyer, M More by this author

Role:: Author

+ Marsh, K More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Tropical Medicine
Role:: Author

+ Newbold, C More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: Weatherall Insti. of Molecular Medicine
Role:: Author

Journal:: Molecular and biochemical parasitology More from this journal
Volume:: 37
Issue:: 2
Pages:: 275-280
Publication date:: 1989-12-01
DOI:: 10.1016/0166-6851(89)90159-x
EISSN:: 1872-9428
ISSN:: 0166-6851

Language:: English
Keywords:: Base Sequence

Molecular Sequence Data

Protozoan Proteins

DNA

Antigens, Protozoan

Polymorphism, Genetic

Polymerase Chain Reaction

Animals

T-Lymphocytes

Epitopes

Amino Acid Sequence

Plasmodium falciparum
Pubs id:: pubs:6073
UUID:: uuid:edddc62f-95f6-4e5c-9a00-47da17145099
Local pid:: pubs:6073
Source identifiers:: 6073
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_edddc62f95f64e5c9a0047da17145099

Terms of use

Copyright date:: 1989

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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