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Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein.

Abstract:
Variation in the immunodominant T cell epitopes Th2R and Th3R of the Plasmodium falciparum circumsporozoite protein has been analysed from Gambian clinical isolates using the polymerase chain reaction. The degree of polymorphism in these epitopes is more extensive than that found in several geographically diverse laboratory isolates. These findings strongly suggest that it will not be feasible to include all variants in a polyvalent subunit sporozoite vaccine.
Publication status:
Published

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Authors


Lockyer, MJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Journal:
Molecular and biochemical parasitology
Volume:
37
Issue:
2
Pages:
275-280
Publication date:
1989-12-05
DOI:
EISSN:
1872-9428
ISSN:
0166-6851
URN:
uuid:edddc62f-95f6-4e5c-9a00-47da17145099
Source identifiers:
6073
Local pid:
pubs:6073

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