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Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1.

Abstract:

Activation of the DNA-damage checkpoint culminates in the inhibition of cyclin-dependent kinase (Cdk) complexes to prevent cell-cycle progression. We have shown recently that Cdk activity is required for activation of the Forkhead transcription factor FoxM1, an important regulator of gene expression in the G2 phase of the cell cycle. Here, we show that FoxM1 is transcriptionally active during a DNA-damage-induced G2 arrest and is essential for checkpoint recovery. Paradoxically, Cdk activity,...

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Publication status:
Published

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Publisher copy:
10.1038/embor.2010.46

Authors


Alvarez-Fernández, M More by this author
Krenning, L More by this author
Aprelia, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
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Journal:
EMBO reports
Volume:
11
Issue:
6
Pages:
452-458
Publication date:
2010-06-05
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
URN:
uuid:edc63971-90e3-42ee-b533-cba72ac6ae81
Source identifiers:
384580
Local pid:
pubs:384580

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