Journal article : Review
Quantitative interpretation of bone marrow biopsies in MPN—what's the point in a molecular age?
- Abstract:
- The diagnosis of myeloproliferative neoplasms (MPN) requires the integration of clinical, morphological, genetic and immunophenotypic findings. Recently, there has been a transformation in our understanding of the cellular and molecular mechanisms underlying disease initiation and progression in MPN. This has been accompanied by the widespread application of high-resolution quantitative molecular techniques. By contrast, microscopic interpretation of bone marrow biopsies by haematologists/haematopathologists remains subjective and qualitative. However, advances in tissue image analysis and artificial intelligence (AI) promise to transform haematopathology. Pioneering studies in bone marrow image analysis offer to refine our understanding of the boundaries between reactive samples and MPN subtypes and better capture the morphological correlates of high-risk disease. They also demonstrate potential to improve the evaluation of current and novel therapeutics for MPN and other blood cancers. With increased therapeutic targeting of diverse molecular, cellular and extra-cellular components of the marrow, these approaches can address the unmet need for improved objective and quantitative measures of disease modification in the context of clinical trials. This review focuses on the state-of-the-art in image analysis/AI of bone marrow tissue, with an emphasis on its potential to complement and inform future clinical studies and research in MPN.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 18.7MB, Terms of use)
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- Publisher copy:
- 10.1111/bjh.19154
Authors
- Publisher:
- Wiley
- Journal:
- British Journal of Haematology More from this journal
- Volume:
- 203
- Issue:
- 4
- Pages:
- 523-535
- Place of publication:
- England
- Publication date:
- 2023-10-19
- Acceptance date:
- 2023-09-30
- DOI:
- EISSN:
-
1365-2141
- ISSN:
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0007-1048
- Pmid:
-
37858962
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1547570
- Local pid:
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pubs:1547570
- Deposit date:
-
2023-11-01
Terms of use
- Copyright holder:
- Ryou et al.
- Copyright date:
- 2023
- Rights statement:
- © 2023 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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