Journal article

Enhancing 31P NMR relaxation rates with a kinetically inert gadolinium complex

Abstract:: The kinetically stable heptadentate gadolinium complex Gd.pDO3A (1.Gd) demonstrates significant ³¹P nuclear magnetic resonance (NMR) relaxation enhancement of biologically relevant phosphate species; adenosine triphosphate (ATP), phosphocreatine (PCr) and inorganic phosphate. Gd.pDO3A (1.Gd) binds these species in fast exchange, enabling the relaxation of the bulk phosphate species in solution. This gives rise to ³¹P relaxation enhancements up to 250-fold higher than those observed for ³¹P relaxation enhancements with the commercial MRI contrast agent Gd.DOTA (DOTAREM), 2. Gd.pDO3A-like complexes may have potential applications as ³¹P magnetic resonance contrast agents, since shortening the T₁ relaxation time of phosphate species would reduce the time needed to acquire ³¹P-MR spectra.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Tear, L. R., Maguire, M. L., Tropiano, M., Yao, K., Farrer, N. J., Faulkner, S., & Schneider, J. E. (2020). Enhancing 31P NMR relaxation rates with a kinetically inert gadolinium complex. Dalton Transactions, 49(9), 2989–2993.

MLA Style

Tear, L. R., et al. “Enhancing 31P NMR Relaxation Rates with a Kinetically Inert Gadolinium Complex.” Dalton Transactions, vol. 49, no. 9, Royal Society of Chemistry, 2020, pp. 2989–93.

Chicago Style

Tear, LR, ML Maguire, M Tropiano, K Yao, NJ Farrer, S Faulkner, and JE Schneider. 2020. “Enhancing 31P NMR Relaxation Rates with a Kinetically Inert Gadolinium Complex.” Dalton Transactions 49 (9): 2989–93.
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Publisher copy:: 10.1039/c9dt03761f

Authors

+ Tear, LR More by this author

Role:: Author

+ Maguire, ML More by this author

Role:: Author

+ Tropiano, M More by this author

Role:: Author

+ Yao, K More by this author

Role:: Author

+ Farrer, NJ More by this author

Department:: CHEMISTRY
Sub department:: Inorganic Chemistry
Role:: Author
ORCID:: 0000-0002-7440-1291

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+ British Heart Foundation More from this funder

Grant:: FS/11/50/29038

Publisher:: Royal Society of Chemistry
Journal:: Dalton Transactions More from this journal
Volume:: 49
Issue:: 9
Pages:: 2989-2993
Publication date:: 2020-02-20
Acceptance date:: 2020-01-22
DOI:: 10.1039/c9dt03761f
EISSN:: 1477-9234
ISSN:: 1477-9226
Pmid:: 32080690

Language:: English
Keywords:: FFR
Pubs id:: 1090128
Local pid:: pubs:1090128
Deposit date:: 2020-04-17

Terms of use

Copyright holder:: The Royal Society of Chemistry
Copyright date:: 2020
Rights statement:: © The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Licence:: CC Attribution (CC BY)

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