Journal article
Reticulin-free quantitation of bone marrow fibrosis in MPNs: utility and applications
- Abstract:
-
Background
Automated quantitation of marrow fibrosis promises to improve fibrosis assessment in myeloproliferative neoplasms (MPNs). However, analysis of reticulin-stained images is complicated by technical challenges within laboratories and variability between institutions.
Methods
We have developed a machine learning model that can quantitatively assess fibrosis directly from H&E-stained bone marrow trephine tissue sections.
Results
Our haematoxylin and eosin (H&E)-based fibrosis quantitation model demonstrates comparable performance to an existing reticulin-stained model (Continuous Indexing of Fibrosis [CIF]) while benefitting from the improved tissue retention and staining characteristics of H&E-stained sections.
Conclusions
H&E-derived quantitative marrow fibrosis has potential to augment routine practice and clinical trials while supporting the emerging field of spatial multi-omic analysis.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Supplementary materials, pdf, 158.0KB, Terms of use)
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(Preview, Version of record, pdf, 4.4MB, Terms of use)
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- Publisher copy:
- 10.1002/jha2.70005
Authors
+ Cancer Research UK
More from this funder
- Funder identifier:
- https://ror.org/054225q67
- Grant:
- EDDPJT-May23/100034
+ Engineering and Physical Sciences Research Council
More from this funder
- Funder identifier:
- https://ror.org/0439y7842
- Grant:
- EP/M013774/1
- Publisher:
- Wiley
- Journal:
- eJHaem More from this journal
- Volume:
- 6
- Issue:
- 2
- Article number:
- e70005
- Place of publication:
- United States
- Publication date:
- 2025-02-27
- Acceptance date:
- 2025-01-28
- DOI:
- EISSN:
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2688-6146
- Pmid:
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40017714
- Language:
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English
- Keywords:
- Pubs id:
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2093076
- Local pid:
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pubs:2093076
- Deposit date:
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2025-04-24
- ARK identifier:
Terms of use
- Copyright holder:
- Ryou et al.
- Copyright date:
- 2025
- Rights statement:
- © 2025 The Author(s). eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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