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Thioamide directed Co(III) catalyzed selective amidation of C(sp3)-H bonds

Abstract:

A mild, oxidant-free and selective Cp*CoIII-catalyzed amidation of thioamides with robust dioxazolone amidating agents via C(sp3)-H bond activation to generate the desired amidated products is reported. The method is efficient and allows for the C-H amidation of a wide range of functionalized thioamides with aryl-, heteroaryl- and alkyl- substituted dioxazolones under the Cp*CoIII catalyzed conditions. The observed regioselectivity towards primary C(sp3)-H activation is supported by computati...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1002/anie.201709273

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Oxford college:
Wadham College
Role:
Author
Publisher:
Wiley-VCH Verlag Publisher's website
Journal:
Angewandte Chemie International Edition Journal website
Volume:
56
Issue:
52
Pages:
16550–16554
Publication date:
2017-11-30
Acceptance date:
2017-10-24
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Pubs id:
pubs:742513
URN:
uri:edae6889-b69f-498f-a337-dce048478e03
UUID:
uuid:edae6889-b69f-498f-a337-dce048478e03
Local pid:
pubs:742513
Paper number:
52

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