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Mutation of the FGFR3 oncogene is an independent and favorable prognostic factor for tumor-specific survival in patients with urothelial carcinoma of the upper urinary tract

Abstract:

AIMS: Urothelial tumors of the upper urinary tract (UUTT) frequently display microsatellite Instability (MSI) and a distinct pathway of tumorigenesis resembling MMR-deficient colorectal cancers has been recognized for MSI-UUTT. For MSS-UUTT however oncogenic mechanisms as in bladder cancer (BC) are debated. Mutation of the oncogene FGFR3 has been linked to lower stage, lower grade and favourable clinical outcome in BC. The aim of this study was to evaluate FGFR3 mutation in MSI and MSS-UUTT. ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences, Biomedical Research Centre
Role:
Author
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Journal:
Verhandlungen der Deutschen Gesellschaft für Pathologie
Volume:
90
Pages:
244-252
Publication date:
2006-01-01
ISSN:
0070-4113
URN:
uuid:edae0d6a-677c-47e4-98f6-96a25601053e
Source identifiers:
120975
Local pid:
pubs:120975
Language:
German

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