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Use of Edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases.

Abstract:

The matrix metalloproteinase (MMP) family has been implicated in the process of a variety of diseases such as arthritis, atherosclerosis, and tumor cell metastasis. We have been designing single-stranded peptides (SSPs) and triple-helical peptides (THPs) as potential discriminatory MMP substrates. Edman degradation sequence and matrix-assisted laser desorption/ionization mass spectrometric (MALDI-MS) analyses of proteolytic activity have been utilized to aid in further substrate design. THP m...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Journal of chromatography. A
Volume:
890
Issue:
1
Pages:
117-125
Publication date:
2000-08-05
DOI:
EISSN:
1873-3778
ISSN:
0021-9673
URN:
uuid:edaa2b38-cffa-4500-b435-1037fbeea7bc
Source identifiers:
227128
Local pid:
pubs:227128

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