Journal article
A survey of simian Plasmodium infections in humans in West Kalimantan, Indonesia
- Abstract:
- The simian parasite Plasmodium knowlesi is the predominant species causing human malaria infection, including hospitalisations for severe disease and death, in Malaysian Borneo. By contrast, there have been only a few case reports of knowlesi malaria from Indonesian Borneo. This situation seems paradoxical since both regions share the same natural macaque hosts and Anopheles mosquito vectors, and therefore have a similar epidemiologically estimated risk of infection. To determine whether there is a true cross-border disparity in P. knowlesi prevalence, we conducted a community-based malaria screening study using PCR in Kapuas Hulu District, West Kalimantan. Blood samples were taken between April and September 2019 from 1000 people aged 6 months to 85 years attending health care facilities at 27 study sites within or close to jungle areas. There were 16 Plasmodium positive samples by PCR, five human malarias (two Plasmodium vivax, two Plasmodium ovale and one Plasmodium malariae) and 11 in which no species could be definitively identified. These data suggest that, if present, simian malarias including P. knowlesi are rare in the Kapuas Hulu District of West Kalimantan, Indonesian Borneo compared to geographically adjacent areas of Malaysian Borneo. The reason for this discrepancy, if confirmed in other epidemiologically similar regions of Indonesian Borneo, warrants further studies targeting possible cross-border differences in human activities in forested areas, together with more detailed surveys to complement the limited data relating to monkey hosts and Anopheles mosquito vectors in Indonesian Borneo.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 10.1MB, Terms of use)
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- Publisher copy:
- 10.1038/s41598-022-21570-0
Authors
+ Department of Foreign Affairs and Trade
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- Funder identifier:
- https://ror.org/023wsvq95
- Publisher:
- Springer Nature
- Journal:
- Scientific Reports More from this journal
- Volume:
- 12
- Issue:
- 1
- Article number:
- 18546
- Place of publication:
- England
- Publication date:
- 2022-11-03
- Acceptance date:
- 2022-09-28
- DOI:
- EISSN:
-
2045-2322
- Pmid:
-
36329096
- Language:
-
English
- Keywords:
- Pubs id:
-
1299847
- Local pid:
-
pubs:1299847
- Deposit date:
-
2025-01-14
- ARK identifier:
Terms of use
- Copyright holder:
- Sugiarto et al
- Copyright date:
- 2022
- Rights statement:
- © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/.
- Licence:
- CC Attribution (CC BY)
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