Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.

Journal article

AIMS: Increasing energy storage capacity by elevating creatine and phosphocreatine (PCr) levels to increase ATP availability is an attractive concept for protecting against ischaemia and heart failure. However, testing this hypothesis has not been possible since oral creatine supplementation is ineffectual at elevating myocardial creatine levels. We therefore used mice overexpressing creatine transporter in the heart (CrT-OE) to test for the first time whether elevated creatine is beneficial ...

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Authors: Lygate, C; Bohl, S; ten Hove, M; Faller, K; Ostrowski, P

• Publication status: Published
• Journal: Cardiovascular research
• Volume: 96
• Issue: 3
• Pages: 466-475
• Publication date: 2012-12-01
• DOI: 10.1093/cvr/cvs272
• EISSN: 1755-3245
• ISSN: 0008-6363
• Language: English
• Keywords: Membrane Transport Proteins; Cell Line; Myocardial Infarction; Mice; Myocardial Reperfusion Injury; Animals; Time Factors; Phosphocreatine; Necrosis; Ventricular Function, Left; Oxidative Stress; Mice, Inbred C57BL; Up-Regulation; Heart Failure; Myocardium; Creatine; Disease Models, Animal; Mice, Transgenic; Glycogen; Magnetic Resonance Imaging, Cine; Energy Metabolism; Mitochondrial Membrane Transport Proteins; Myocardial Stunning; Ventricular Remodeling; Mitochondria, Heart