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Tissue repair and the dynamics of the extracellular matrix.

Abstract:

Repair of tissue after injury depends on the synthesis of a fibrous extracellular matrix to replace lost or damaged tissue. Newly deposited extracellular matrix is then re-modeled over time to emulate normal tissue. The extracellular matrix directs repair by regulating the behavior of the wide variety of cell types that are mobilized to the damaged area in order to rebuild the tissue. Acute inflammation, re-epithelialization, and contraction all depend on cell-extracellular matrix interaction...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Williams, LV More by this author
Schwarzbauer, JE More by this author
Journal:
The international journal of biochemistry and cell biology
Volume:
36
Issue:
6
Pages:
1031-1037
Publication date:
2004-06-05
DOI:
EISSN:
1878-5875
ISSN:
1357-2725
URN:
uuid:ed88bed4-9e44-4ee0-8b8b-1ea99781df1e
Source identifiers:
225563
Local pid:
pubs:225563

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