Follicular and marginal zone B cells fail to cross-present MHC class I-restricted epitopes derived from viral particles.
Viruses and virus-like particles (VLPs) are known to be potent inducers of B cell as well as Th cell and CTL responses. It is well established that professional APCs such as dendritic cells (DCs) and macrophages efficiently process viral particles for both MHC class I- and MHC class II-associated presentation, which is essential for induction of CTL and Th cell responses, respectively. Less is known, however, about the ability of B cells to present epitopes derived from viral particles to T c...Expand abstract
- Publisher copy:
- Copyright date: