Loss of Perineuronal Net in ME7 Prion Disease.

Journal article

Microglial activation and behavioral abnormalities occur before neuronal loss in experimental murine prion disease; the behavioral changes coincide with a reduction in synaptic plasticity. Because synaptic plasticity depends on an intact perineuronal net (PN), a specialized extracellular matrix that surrounds parvalbumin (PV)-positive GABAergic (gamma-aminobutyric acid [GABA]) inhibitory interneurons, we investigated the temporal relationships between microglial activation and loss of PN and ...

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Authors: Franklin, S; Love, S; Greene, JR; Betmouni, S

• Publication status: Published
• Journal: Journal of neuropathology and experimental neurology
• Volume: 67
• Issue: 3
• Pages: 189-199
• Publication date: 2008-03-01
• DOI: 10.1097/nen.0b013e3181654386
• EISSN: 1554-6578
• ISSN: 0022-3069
• Language: English
• Keywords: Microglia; Interneurons; Receptors, N-Acetylglucosamine; Plant Lectins; Animals; gamma-Aminobutyric Acid; Encephalitis; Mice; Mice, Inbred C57BL; Female; Disease Models, Animal; Nerve Degeneration; Extracellular Matrix; Parvalbumins; Staining and Labeling; PrPSc Proteins; Hippocampus; Neural Pathways; Neuronal Plasticity; Gliosis; Disease Progression; Prion Diseases