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Journal article

Interleukin 13-mediated colitis in the absence of IL-4Rα signalling.

Abstract:

Sufficient evidence points to interleukin 13 (IL-13) as an important pathological factor in UC and raises hopes to a promising new treatment strategy.1–3 However, the outcomes of two recent clinical trials, both published in Gut 2015, suggest otherwise.4 ,5 A commentary published in the same issue described these results as crushing the enthusiasm for anti-IL-13 treatment in UC.6 In this letter, we show evidence that the disease outcome is determined by the type of signalling pathway used by ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/gutjnl-2016-313208

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Gastroenterology Foundation of South Africa More from this funder
South African Research Chair Initiative More from this funder
National Research Foundation More from this funder
Carnegie Corporation More from this funder
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
Gut Journal website
Publication date:
2017-02-01
Acceptance date:
2017-02-05
DOI:
ISSN:
0017-5749 and 1468-3288
Source identifiers:
683980
Language:
English
Keywords:
Pubs id:
pubs:683980
UUID:
uuid:ed81cd46-8a0d-4691-8917-863139212e79
Local pid:
pubs:683980
Deposit date:
2017-05-05

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