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Interleukin 13-mediated colitis in the absence of IL-4Rα signalling.

Abstract:

Sufficient evidence points to interleukin 13 (IL-13) as an important pathological factor in UC and raises hopes to a promising new treatment strategy.1–3 However, the outcomes of two recent clinical trials, both published in Gut 2015, suggest otherwise.4 ,5 A commentary published in the same issue described these results as crushing the enthusiasm for anti-IL-13 treatment in UC.6 In this letter, we show evidence that the disease outcome is determined by the type of signalling pathway used by ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1136/gutjnl-2016-313208

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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Gastroenterology Foundation of South Africa More from this funder
National Research Foundation More from this funder
South African Research Chair Initiative More from this funder
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
Gut Journal website
Publication date:
2017-02-05
Acceptance date:
2017-02-05
DOI:
ISSN:
1468-3288 and 0017-5749
Pubs id:
pubs:683980
URN:
uri:ed81cd46-8a0d-4691-8917-863139212e79
UUID:
uuid:ed81cd46-8a0d-4691-8917-863139212e79
Local pid:
pubs:683980

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