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Journal article

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection.

Abstract:

Identification of the transmitted/founder virus makes possible, for the first time, a genome-wide analysis of host immune responses against the infecting HIV-1 proteome. A complete dissection was made of the primary HIV-1-specific T cell response induced in three acutely infected patients. Cellular assays, together with new algorithms which identify sites of positive selection in the virus genome, showed that primary HIV-1-specific T cells rapidly select escape mutations concurrent with falli...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20090365

Authors


Goonetilleke, N More by this author
Salazar-Gonzalez, JF More by this author
Ferrari, G More by this author
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Journal:
The Journal of experimental medicine
Volume:
206
Issue:
6
Pages:
1253-1272
Publication date:
2009-06-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:ed812f7f-9de0-42a3-9fec-1ea1e54bd2d9
Source identifiers:
34740
Local pid:
pubs:34740

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