The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection.

Journal article

Identification of the transmitted/founder virus makes possible, for the first time, a genome-wide analysis of host immune responses against the infecting HIV-1 proteome. A complete dissection was made of the primary HIV-1-specific T cell response induced in three acutely infected patients. Cellular assays, together with new algorithms which identify sites of positive selection in the virus genome, showed that primary HIV-1-specific T cells rapidly select escape mutations concurrent with falli...

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Authors: Goonetilleke, N; Liu, M; Salazar-Gonzalez, J; Ferrari, G; Giorgi, E

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 206
• Issue: 6
• Pages: 1253-1272
• Publication date: 2009-06-01
• DOI: 10.1084/jem.20090365
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Amino Acid Sequence; Epitopes; Sequence Analysis, Protein; HIV Infections; Models, Theoretical; Molecular Sequence Data; HIV-1; Immune System; CHAVI Clinical Core B; Evolution, Molecular; T-Lymphocytes; Humans; Viremia; Mutation; Genome, Viral; Cytokines; Viral Proteins