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Validation of the survival model including cardiac substructure dosimetry in NSCLC

Abstract:
In lung cancer radiotherapy (RT) high doses are delivered to the heart. We found significant associations between death rate (DR) and high left atrial wall (LAWall) volumes receiving 63-69Gy (LAWallV63-69) and any new or worsening ischaemic or rhythm ECG changes within 6 months of RT in a prospective isotoxic dose-escalation trial of 78 locally advanced non-small cell lung cancer (LA-NSCLC) patients. Here we aim to validate these findings in an independent retrospective cohort.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/S0167-8140(18)31057-0

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Panakis, N More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Landau, DB More by this author
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Publisher:
Elsevier Publisher's website
Volume:
127
Pages:
S383-S384
Publication date:
2018-06-18
Acceptance date:
2018-02-09
DOI:
EISSN:
1879-0887
ISSN:
0167-8140
Pubs id:
pubs:900874
URN:
uri:ed73b7c5-758d-4a9f-ab2e-dc09af9c68ea
UUID:
uuid:ed73b7c5-758d-4a9f-ab2e-dc09af9c68ea
Local pid:
pubs:900874

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