Journal article
The importance of p53 pathway genetics in inherited and somatic cancer genomes
- Abstract:
- Decades of research have shown that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that commonly inherited genetic variants in the p53 pathway also affect the incidence of a broad range of cancers more than variants in other pathways. The cancer-associated single nucleotide polymorphisms (SNPs) of the p53 pathway have strikingly similar genetic characteristics to well-studied p53 pathway cancer-causing somatic mutations. Our results enable insights into p53-mediated tumour suppression in humans and into p53 pathway-based cancer surveillance and treatment strategies.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 2.2MB, Terms of use)
-
- Publisher copy:
- 10.1038/nrc.2016.15
Authors
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Reviews Cancer More from this journal
- Volume:
- 16
- Issue:
- 4
- Pages:
- 251–265
- Publication date:
- 2016-03-24
- Acceptance date:
- 2016-02-02
- DOI:
- EISSN:
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1474-1768
- ISSN:
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1474-175X
- Language:
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English
- Pubs id:
-
pubs:611082
- UUID:
-
uuid:ed6eff37-48de-4029-b259-2a453745fb40
- Local pid:
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pubs:611082
- Source identifiers:
-
611082
- Deposit date:
-
2016-03-18
- ARK identifier:
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2016
- Rights statement:
- © 2016 Macmillan Publishers Limited
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at https://doi.org/10.1038/nrc.2016.15
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