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Gene loops juxtapose promoters and terminators in yeast.

Abstract:

Mechanistic analysis of transcriptional initiation and termination by RNA polymerase II (PolII) indicates that some factors are common to both processes. Here we show that two long genes of Saccharomyces cerevisiae, FMP27 and SEN1, exist in a looped conformation, effectively bringing together their promoter and terminator regions. We also show that PolII is located at both ends of FMP27 when this gene is transcribed from a GAL1 promoter under induced and noninduced conditions. Under these con...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ng1411

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
36
Issue:
9
Pages:
1014-1018
Publication date:
2004-01-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:ed6e1512-fef0-4532-808b-b3529730e8f1
Source identifiers:
15846
Local pid:
pubs:15846

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