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A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function.

Abstract:

The nematode Caenorhabditis elegans is an established model organism for studying neurobiology. UNC-63 is a C. elegans nicotinic acetylcholine receptor (nAChR) α-subunit. It is an essential component of the levamisole-sensitive muscle nAChR (L-nAChR) and therefore plays an important role in cholinergic transmission at the nematode neuromuscular junction. Here, we show that worms with the unc-63(x26) allele, with its αC151Y mutation disrupting the Cys-loop, have deficient muscle function refle...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110.177238

Authors


Al-Diwani, A More by this author
Maynard, TP More by this author
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Journal:
The Journal of biological chemistry
Volume:
286
Issue:
4
Pages:
2550-2558
Publication date:
2011-01-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:ed653a30-136b-4def-b5de-30707d29e2f0
Source identifiers:
244264
Local pid:
pubs:244264

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