Commentary: the 1944 patulin trial: the first properly controlled multicentre trial conducted under the aegis of the British Medical Research Council.

Journal article

The 1948 report of the British Medical Research Council's randomized trial of streptomycin for pulmonary tuberculosis is widely regarded as marking the beginning of the modern history of controlled clinical trials. Four years earlier, however, a methodologically sophisticated multicentre trial conducted under the aegis of the Medical Research Council was reported, which assessed the effects of the antibiotic patulin on the course of common colds. Philip D'Arcy Hart and Joan Faulkner (later Jo...

Expand abstract

Authors: Chalmers, I; Clarke, M

• Publication status: Published
• Journal: International journal of epidemiology
• Volume: 33
• Issue: 2
• Pages: 253-260
• Publication date: 2004-04-01
• DOI: 10.1093/ije/dyh162
• EISSN: 1464-3685
• ISSN: 0300-5771
• Language: English
• Keywords: Multicenter Studies as Topic; England; Common Cold; Patulin; Humans; Randomized Controlled Trials as Topic; Government Agencies; Penicillins; History, 20th Century