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Crystal structure of the Bacillus subtilis phosphodiesterase PhoD reveals an iron and calcium-containing active site.

Abstract:

The PhoD family of extra-cytoplasmic phosphodiesterases are among the most commonly occurring bacterial phosphatases. The exemplars for this family are the PhoD protein of Bacillus subtilis and the phospholipase D of Streptomyces chromofuscus. We present the crystal structure of B. subtilis PhoD. PhoD is most closely related to purple acid phosphatases (PAPs) with both types of enzyme containing a tyrosinate-ligated Fe(3+) ion. However, the PhoD active site diverges from that found in PAPs an...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m114.604892

Authors


Rodriguez, F More by this author
Lillington, J More by this author
Johnson, S More by this author
Timmel, CR More by this author
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Publisher:
American Society for Biochemistry and Molecular Biology Inc.
Journal:
The Journal of biological chemistry
Volume:
289
Issue:
45
Pages:
30889-30899
Publication date:
2014-11-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:ed4a05f4-03a3-496a-9f04-6c6c3bc2ffe3
Source identifiers:
484228
Local pid:
pubs:484228

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