Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways.

Journal article

In response to DNA damage, eukaryotic cells must rapidly load DNA repair proteins onto damaged chromatin. Chromatin recruitment often entails ubiquitination of a damage-specific DNA repair protein, interaction with a ubiquitin binding factor, assembly of a multisubunit DNA repair complex, and eventually a deubiquitination event once the DNA repair reaction has been completed. This review focuses on the recent discoveries in the Fanconi Anemia (FA) and DNA double-strand break (DSB) repair path...

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Authors: Cohn, M; D'Andrea, A

• Publication status: Published
• Journal: Molecular cell
• Volume: 32
• Issue: 3
• Pages: 306-312
• Publication date: 2008-11-01
• DOI: 10.1016/j.molcel.2008.10.009
• EISSN: 1097-4164
• ISSN: 1097-2765
• Language: English
• Keywords: Homeostasis; Ubiquitination; Ubiquitin-Activating Enzymes; Fanconi Anemia; DNA Breaks, Double-Stranded; DNA Repair; Chromatin Assembly and Disassembly; Humans; Chromatin; DNA Damage; Ubiquitin