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Genetic Association Study Design

Abstract:

Association studies can be performed using any type of genetic polymorphism, but the one most commonly used is the single nucleotide polymorphism (SNP). This is because of its abundance across the genome, comprising 90% of all human variation. The aim of this chapter is to review various aspects of population-based study design, aimed at uncovering common genetic variations underlying complex traits. There is the realization that many of these variants lie ingene deserts and their biological ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Publisher:
Elsevier Inc.
Pages:
25-48
Publication date:
2011
DOI:
URN:
uuid:ed2df950-37bf-435e-bccc-1999ace1b447
Source identifiers:
426130
Local pid:
pubs:426130
Language:
English

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