Formation of complexes between self-peptides and MHC class II molecules in cells defective for presentation of exogenous protein antigens.

Journal article

A vertebrate immune response is initiated by the presentation of foreign protein Ag to MHC class II-restricted T lymphocytes by specialized APC. Presentation of self-peptides in association with MHC class II molecules is also necessary for the induction of T cell tolerance. It is important to understand whether functionally divergent APC are responsible for delivering these distinct signals to class II-restricted T cells. Here we examine the ability of I-Ad surface molecules expressed in dive...

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Authors: Bikoff, E

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 149
• Issue: 1
• Pages: 1-8
• Publication date: 1992-07-01
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: T-Lymphocytes; RNA Splicing; Autoantigens; Immunoglobulin G; Mice; Antigen-Presenting Cells; Histocompatibility Antigens Class II; Transfection; Lymphocyte Activation; Peptides; Cells, Cultured; Animals; Antigens, Differentiation, B-Lymphocyte