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Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59.

Abstract:

CD2 is a T lymphocyte cell-adhesion molecule (CAM) belonging to the immunoglobulin superfamily (IgSF) which mediates transient adhesion of T cells to antigen-presenting cells and target cells. Reported ligands for human CD2 include the structurally-related IgSF CAMs CD58 (LFA-3) and CD48 as well as, more controversially, the unrelated cell-surface glycoprotein CD59. Using surface plasmon resonance technology, which avoids several pitfalls of conventional binding assays, we recently reported t...

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Publication status:
Published

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Publisher copy:
10.1021/bi00199a043

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Biochemistry
Volume:
33
Issue:
33
Pages:
10149-10160
Publication date:
1994-08-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:ed0b46ac-b845-4fc1-ac53-efa5a2f7b37b
Source identifiers:
9145
Local pid:
pubs:9145

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