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Regulatory T cell enrichment by IFN-γ conditioning.

Abstract:

IFN-γ was originally characterized as a proinflammatory cytokine with T helper type 1 inducing activity, but it is now clear that it also has important immunoregulatory functions. Regulatory T cells play an important role in models of autoimmunity, GVHD, and transplantation, and offer potential as a cellular therapy. In rodent models, in vivo-generated CD25(+)CD4(+) T cells can prevent allograft rejection, but therapeutic exploitation of Treg will more likely depend on protocols that allow th...

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Bushell, A More by this author
Journal:
Methods in molecular biology (Clifton, N.J.)
Volume:
677
Pages:
281-301
Publication date:
2011
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
URN:
uuid:ed04436b-5f59-4524-be22-7f99bb63208e
Source identifiers:
136000
Local pid:
pubs:136000

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