Taenia solium: characterization of a small heat shock protein (Tsol-sHSP35.6) and its possible relevance to the diagnosis and pathogenesis of neurocysticercosis.

Journal article

A cDNA encoding for a predicted small heat shock protein (sHSP), Tsol-sfISP35.6, has been isolated by antibody screening of a Taenia solium c-DNA library. The clone was a full-length sequence (1172 bp) with an open reading frame of 945 bp and encoded for a 314 amino acid protein with deduced molecular mass of 35.6 kDa, isoelectric point of 5.6 arid the characteristic HSP20/alpha-crystallin domain duplicated. It was highly conserved, with a high sequence similarity with other platyhelminth sHS...

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Authors: Ferrer, E; González, L; Foster-Cuevas, M; Cortéz, M; Dávila, I

• Journal: Experimental parasitology
• Volume: 110
• Issue: 1
• Pages: 1-11
• Publication date: 2005-05-01
• DOI: 10.1016/j.exppara.2004.11.014
• EISSN: 1090-2449
• ISSN: 0014-4894
• Language: English
• Keywords: Base Sequence; Antigens, Helminth; Rabbits; Electrophoresis, Polyacrylamide Gel; Immune Sera; Sequence Alignment; Sensitivity and Specificity; Enzyme-Linked Immunosorbent Assay; Swine; Molecular Weight; DNA, Complementary; Blotting, Western; Animals; Isoelectric Point; Antibodies, Helminth; Neurocysticercosis; Heat-Shock Proteins; Humans; Recombinant Proteins; Open Reading Frames; Sequence Homology, Amino Acid; Molecular Sequence Data; Amino Acid Sequence; Taenia solium