- Abstract:
-
Myasthenia gravis (MG) is mediated by autoantibodies to the acetylcholine receptor (AChR), expressed in muscle and rare thymic myoid cells. Most early-onset cases show thymic lymph node-type infiltrates, including pre-activated plasma cells spontaneously producing anti-AChR antibodies. Since these are not evident in the associated thymomas found in another 10% of MG patients, AChR-specific B cells must be autosensitized elsewhere. Unexpectedly, at diagnosis, >70% of MG/thymoma patients als...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/intimm/dxg088
-
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- Journal:
- International immunology
- Volume:
- 15
- Issue:
- 8
- Pages:
- 903-913
- Publication date:
- 2003-08-05
- DOI:
- EISSN:
-
1460-2377
- ISSN:
-
0953-8178
- URN:
-
uuid:ecede586-c970-4244-a16e-dc384537d456
- Source identifiers:
-
115443
- Local pid:
- pubs:115443
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Spontaneous production of anti-IFN-alpha and anti-IL-12 autoantibodies by thymoma cells from myasthenia gravis patients suggests autoimmunization in the tumor.
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