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Spontaneous production of anti-IFN-alpha and anti-IL-12 autoantibodies by thymoma cells from myasthenia gravis patients suggests autoimmunization in the tumor.

Abstract:

Myasthenia gravis (MG) is mediated by autoantibodies to the acetylcholine receptor (AChR), expressed in muscle and rare thymic myoid cells. Most early-onset cases show thymic lymph node-type infiltrates, including pre-activated plasma cells spontaneously producing anti-AChR antibodies. Since these are not evident in the associated thymomas found in another 10% of MG patients, AChR-specific B cells must be autosensitized elsewhere. Unexpectedly, at diagnosis, >70% of MG/thymoma patients als...

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Publication status:
Published

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Publisher copy:
10.1093/intimm/dxg088

Authors


Matthews, I More by this author
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Journal:
International immunology
Volume:
15
Issue:
8
Pages:
903-913
Publication date:
2003-08-05
DOI:
EISSN:
1460-2377
ISSN:
0953-8178
URN:
uuid:ecede586-c970-4244-a16e-dc384537d456
Source identifiers:
115443
Local pid:
pubs:115443

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