Journal article icon

Journal article

DNA triplex formation with 5-dimethylaminopropargyl deoxyuridine.

Abstract:

We have prepared triplex-forming oligonucleotides containing the nucleotide analogue 5-dimethylaminopropargyl deoxyuridine (DMAPdU) in place of thymidine and examined their ability to form intermolecular triple helices by thermal melting and DNase I footprinting studies. The results were compared with those for oligonucleotides containing 5-aminopropargyl-dU (APdU), 5-guanidinopropargyl-dU (GPdU) and 5-propynyl dU (PdU). We find that DMAPdU enhances triplex stability relative to T, though sli...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/nar/gkn1060

Authors


Rusling, DA More by this author
Srinivasan, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Nucleic acids research
Volume:
37
Issue:
4
Pages:
1288-1296
Publication date:
2009-03-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:ecebf8f4-ad8b-4209-8df3-feb4020edf1c
Source identifiers:
400011
Local pid:
pubs:400011

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP